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In a 52 week study including human insulin (NPH insulin) as comparator (6.7 units/kg/day), Sprague Dawley rats were dosed subcutaneously with insulin degludec at 3.3, 6.7, and 10 units/kg/day, resulting in 5 times the human exposure (AUC) when compared to a human subcutaneous dosage of 0.75 units/kg/day
Most patients tolerate hydroxocobalamin injections well
Dosing typically starts low and is gradually increased over several weeks to help the body adjust and minimize side effects
Accessed Apr 14, 2025.
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