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Similarly, in a randomized trial of 108 IBS patients, a Mediterranean low-FODMAP diet improved symptoms and maintained relief at 6 months, with fecal metabolomic shifts indicating reduced total and branched-chain fatty acids, consistent with a microbiota-metabolite mechanism sustaining clinical improvement (Gibson and Shepherd, 2010)

[38] noted GLP-1 binds to receptors on vagal afferent neurons, which decreased postprandial pancreatic digestive enzyme secretion

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