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While some of the trials reported a decrease in appetite as a side effect, like the ADJUNCT trials (60), it should be noted that this is one of the main mechanisms of action of these drugs to achieve weight loss
If the headaches are part of the body adjusting to the medication, they may persist intermittently for the first couple weeks, particularly after dose increases. In general, though, most headaches are temporary and tend to resolve within a few hours to a couple of days, he adds
This continuous receptor stimulation provides uninterrupted appetite control, whereas liraglutide levels dip between doses, potentially allowing brief windows of increased hunger
The addition of a ghrelin mimetic may also aid through other ghrelin-related actions, including neuroprotection
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