Smooth muscle relaxation induced by NO in the corpus cavernosum is mediated by cyclic GMP (cGMP)
Over time, this cumulative oxidative stress impairs mitochondrial function, disrupts cell signaling, and promotes inflammation - all hallmarks of biological aging
It is a particular factor during the early phases of treatment and mentioned as something to monitor in cases of severe anaemia in NICE guidelines
Contact your GP if you experience: Unexpected symptoms after starting B12 supplementation, including persistent skin reactions, gastrointestinal disturbance, or mild allergic manifestations Neurological symptoms such as significant tingling, numbness, weakness, or balance problemsthese may indicate B12 deficiency paradoxically, or alternative neurological conditions requiring assessment Unexplained fatigue or malaise that develops or worsens despite supplementation Concerns about medication interactions , particularly if taking metformin, proton pump inhibitors, or other medications affecting B12 metabolism [2] [4] Seek emergency medical attention (call 999) if you develop signs of a severe allergic reaction following B12 injection, including facial swelling, difficulty breathing, or widespread urticaria
These include
