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Zinc regulates Nox1 expression through a NF-B and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells
Blood vessels matter because angiogenesis improves oxygen and nutrient delivery to injured tissue, which supports wound, tendon, muscle, and gut lining repair in preclinical models
This rapid kinetics requires multi-daily administrations (2-3 times per day) to maintain chronic stimulation, typically in synergy with an extended-duration GHRH analog such as CJC-1295 DAC
10.3389/fcell.2021.756315 Front Cell Dev Biol
