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These challenges might lead to substantial legal costs and influence overall company performance, potentially resulting in market volatility

Limited brain penetration of agonists: Studies using fluorescently labelled GLP-1 receptor agonists like semaglutide and liraglutide have shown very limited penetration into most brain regions beyond the circumventricular organs areas where the bloodbrain barrier is less effective and allows the brain to sample blood contents

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Overall, this case suggests a role for prolonged fasting in combination with a GLP-1 as a bridge to bariatric surgery in carefully selected, highly-motivated patients