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Given the intractable pediatric obesity epidemic and associated rise in type 2 diabetes in youth, made worse by the COVID-19 pandemic related shutdowns and disruptions in opportunities for exercise and play in youth, this new class of medications will certainly benefit children with morbid obesity and type 2 diabetes

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This surge of enthusiasm is bolstered by the ongoing scrutiny of 24 clinical trials cataloged on ClinicalTrials.gov as of November 26, 2023 (Table 2), which are dedicated to probing the pharmacological properties of glutaminase inhibitors and delving into their immunogenic characteristics

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It is a conditionally essential amino acid that the body uses in hundreds of biochemical reactions