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The demonstration was made that the alterations in the expression of iron maintenance proteins in PR cells were impeded by MLT, which suppressed the GSK-3 signaling pathway and hindered Fyn-dependent Nrf2 nuclear translocation (150)

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We propose that hepatic activation of TH signaling has insulinotropic and glucose-lowering effects, as it is able to increase non-12-OH FXR-antagonistic BA levels through shaping the BA composition by repressing hepatic CYP8B1, thereby enhancing the GLP-1 production via suppressing intestinal FXR signaling