In BV-2 microglia, berberine down-regulates lipopolysaccharide- or interferon--induced iNOS and cyclooxygenase-2 (COX-2) level, and inhibits inflammatory cytokines expression (for example IL-6, IL-1, TNF-) (Lu et al., 2010)
ASK1, also known as MAP3K5, activates the downstream p38-JNK1/2 signalling pathway, thereby promoting inhibition of lipid and glucose metabolism 34,35,36 and driving a strong inflammatory response 37
For beginners, the short version is simpler: treat printed C-rating as a rough filter, then judge real performance by sag, heat, and consistent behavior under load
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