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To address this fear, clinicians should be knowledgeable about the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) study, which showed that insulin glargine 100 U/mL has a neutral effect on cardiovascular outcomes overall and a beneficial effect on microvascular complications, and the DEVOTE study, which established insulin degludec 100 U/mL as having a similar effect to insulin glargine 100 U/mL on the risk of cardiovascular events