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Concurrently, GLP-1 stimulates the translocation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) into the nucleus via the PKA/ERK signaling pathway, where Nrf2 induces transcription of genes for SOD, GPx, catalase, thioredoxin, and other antioxidant enzymes, further enhancing the cellular antioxidant defense system
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Nanotechnology in Drug Delivery, 129162 Ferreira, S
Patients and methods Patients This retrospective study included patients with T2DM who received outpatient or inpatient care at the Hospital of the University of Occupational and Environmental Health, Japan between September 2010 and August 2019, who underwent GLP-1 RA treatment for the first time, and who continued treatment with liraglutide or dulaglutide for at least 12 months
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