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The Phase 2 trial (NEJM 2023) reported an average body-weight reduction of about 24% at 48 weeks at the highest dose
The removal triggered a wind-down period during which compounding pharmacies could continue to produce tirzepatide for existing patients but were required to cease new compounding after the period ended
A particular challenge will be the transition from pre-clinical to clinical studies, since there are likely to be species differences
These findings reinforce the importance of continued monitoring, early detection, and intervention strategies to possibly mitigate the growing burden of vitamin B12 deficiency in both public and private healthcare settings (23)
This common concern affects many patients starting glucagon-like peptide-1 (GLP-1) receptor agonists like semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), or dulaglutide (Trulicity) for type 2 diabetes or weight management
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