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Specifically, NPY and Y1 receptor knock-out mice showed decreased eosinophils in the bronchoalveolar lavage fluid, as well as decreased circulating immunoglobulin E (IgE) levels, compared to wild-type mice under allergic conditions [178]

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And absent more rigorous studies, the team warned, it will remain difficult to convince the broader medical community that this so-called wonderful compound meets the criteria of a legitimate therapeutic agent. But it turns out, one group had begun to give it a go anyway