This binding depends on the intact N-terminal hexapeptide sequencemechanical shear stress from shaking or direct powder impact can break peptide bonds in that sequence, reducing receptor binding affinity by 1540%
GLP-1s, like semaglutide and tirzepatide, are medications that work by mirroring naturally occurring hormones in the body
But the decades of safety data in wound healing applications, combined with the natural occurrence of GHK in human plasma, gives researchers confidence in its risk profile
Marzetti E, Calvani R, Cesari M, Buford TW, Lorenzi M, Behnke BJ, Leeuwenburgh C
Theory 3: Its a brain drug