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Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality

This makes injections highly effective for pernicious anaemia and other malabsorption syndromes, including post-gastrectomy states, Crohn's disease affecting the terminal ileum, and certain medications that interfere with B12 uptake

The foundational evidence is a 2017 Cell study in aged and progeroid mice , where FOXO4-DRI reduced senescent-cell burden and restored markers such as fur density and renal function [3]

Maximum: Up to roughly 4.5 mg weekly in advanced protocols, the dose tied to the greatest weight loss in early trials [4]

You can take more when you are sick or particularly stressed out