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A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient
& Long, J
Biologically active vitamin B12 compounds in foods for preventing deficiency among vegetarians and elderly subjects
Self-injecting vitamin B12 Quick and painless jabs after a B12 deficiency diagnosis 2 years ago I was diagnosed with B12 deficiency two years ago, at the start of COVID-19 lockdown in the UK
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