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Moreover, we validated the relationship between GSH-regulated replication stress and JMF4073 sensitivity in a number of TKI-insensitive human CML blast-crisis cells, and present the evidence of the synthetic lethality by targeting glutathione biosynthesis with JMF4073 in these cells
75 While excessive activation of THR may lead to cardiac abnormalities, 42 specific THR activators primarily target the liver, inducing hepatic fatty acid oxidation and reducing steatosis and hyperlipidemia in rats and mice with genetically or diet-induced T2DM
Healthy cartilage exhibits extremely low shear friction, whereas elevated shear accelerates wear, induces degradative enzymes, and establishes a positive feedback that promotes OA (Szabo et al., 2023
Adv Pediatr
Mt s nghin cu cn cho thy glutathione c tc dng chng to hc t gim sc t da, lm sng tng mu da, ngn nga lo ha
