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Reported Side Effects (Typically Rare and Mild) Temporary lethargy or slight fatigue
the available information comes primarily from the phase 2 randomised controlled trial (NEJM, 2023) and from broader experience with the GLP-1 receptor agonist drug class
It increases our basal metabolic rate (how much energy we burn at rest), meaning we burn more energy throughout the day, and it promotes the breakdown of stored fat for fuel
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The FDA confirmed that the tirzepatide shortage was resolved, and compounding pharmacies and outsourcing facilities lost the authority to make it in 2025
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