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Withdrawing the needle smoothly and immediately applying gentle pressure with sterile gauze if needed

show that PLGA nanoparticles covalently coupled with the myelin proteolipid protein epitope PLP 139151 induce potent antigen-specific tolerance in the relapsing-remitting model, preventing and treating relapsing EAE through reduced CNS infiltration of Th1/Th17 cells and suppression of epitope spread (176)