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Patients should also be taught simple strategies to reduce side effects, such as drinking more fluids, increasing fiber slowly, and adjusting food choices when symptoms flare
Tirzepatide pushed this further, achieving up to 22 percent weight loss in the SURMOUNT-1 trial
A 2026 analysis in eClinicalMedicine , part of The Lancet family of journals, found that patients regained about 60% of the weight they lost within the first year after stopping GLP-1 therapy
The medication is simply more concentrated in the higher dose
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