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Typically, dentures need replacement every 5-7 years, though proper care may extend their lifespan

Therefore, after Fe 2+ is excreted, it is oxidized to Fe 3+ by iron transport auxiliary proteins on the basolateral membrane or by ceruloplasmin, after which the generated pools of Fe 3+ bind with Tf to enter the plasma, forming serum iron, or they are transferred to cells that require iron