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A pilot study has indicated that metformin may enhance feelings of satiety and decrease food-related anxiety in certain individuals with PWS, potentially through the mechanism of improved insulin sensitivity [39]
The 8mg group showed a 21.6 percentage point difference versus placebo
Even high infusion doses produced no signs of pituitary fatigue
F.et al (2022)
Cagrilintide acts at amylin receptors (AMY1, AMY2, AMY3 heterodimers of the calcitonin receptor with receptor activity-modifying proteins) and at the calcitonin receptor itself
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