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The GI side effects that occur at higher doses without titration are significant enough to derail adherence completely

Data availability The data in this study are available from the corresponding author K.H., upon reasonable request

Role of Ascorbate in the Generation of Endogenous Oxalate Oxalate is present in many foods such as spinach, chard, nuts, black pepper, poppy seeds, and also occurs as a result of the metabolism of ascorbic acid, and the amino acids glycine, serine, and 4-hydroxyproline as well as metabolism of ethanolamine

The reconstituted solution requires refrigeration and careful handling to maintain potency

This transition could help in sustaining motivation and adherence to treatment over the long term. This maintenance approach is currently being investigated