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We, therefore, speculate that these signaling differences between DA and NE may provide islet cells with an additional mechanism for finer temporal control of hormone release that may be especially critical for differential metabolic adaptations to states of acute and chronic stress when concentrations of circulating catecholamines are altered

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According to the World Health Organizations International Agency for Research on Cancer, 19.29 million new cancer cases and 9.7 million cancer-related deaths were recorded globally in 2022 (Sun et al., 2022)