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Indeed, for neonatal HSV-1 infections the olfactory route is frequently deemed responsible and widely described as the result of close contact between the newborn olfactory tissue and HSV-1 virions present in the birth canal of the mother at the time of birth (Burgos et al., Figure 1A

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Additional risk factors encompass age, obesity (BMI 30), inadequate diet, alcohol consumption, anxiety and depression, working in extremely hot conditions, the presence of Cushings syndrome, mumps, hypospadias, anemia, diabetes, metabolic syndrome, and thyroid diseases (37, 38)

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This usually involves tearing off the plastic or metal seals to expose the rubber stoppers underneath