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Higher doses, such as 15 mg/d, have also been tested in short-term studies, though these did not significantly increase plasma spermidine levels owing to pre-systemic conversion into other polyamines, such as spermine (Reference Senekowitsch, Wietkamp and Grimm20)

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In a study of 30 perimenopausal women with uterine fibroids, after conservative treatment with SGD, more than 60% of patients with fibroids smaller than a fist size (with dysmenorrhea and/or main complaint of dysmenorrhea) showed some degree of improvement in dysmenorrhea after traditional Chinese medicine treatment, while those with fibroids larger than a fist size showed no significant improvement (Sakamoto et al., 1998)

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