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Glutathione peroxidase (GPx)-deficient mice spontaneously develop colitis 4
Philp and colleagues (FASEB J, 2003) showed the LKKTETQ site alone is sufficient to promote endothelial cell migration and angiogenesis in aortic ring and chick chorioallantoic assays, and Sosne and colleagues (FASEB J, 2010) mapped further activities onto short internal sequences of the parent protein
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Depending on the dosage, undesirable side effects could range from minor to severe
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