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This significant reduction underscores the efficacy of VNS in modulating food intake and energy expenditure (Yao et al., 2018)

Volume depletion and hypotension risks are increased with both medications, especially in elderly patients or those taking diuretics

Other health conditions, such as obesity, smoking, diabetes, or heart disease, may have contributed

These are still FDA-approved drugs requiring a prescription to provide to a patient, and licensed prescriberssuch as physicians, physician assistants (PAs) and advanced practice registered nurses (APRNs)must still adhere to their professional ethical obligations and the standard of practice for their profession

It has not received marketing authorisation from the MHRA, the EMA, or the US Food and Drug Administration (FDA), and therefore cannot be legally prescribed or dispensed outside of authorised clinical research settings