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Cardiovasc Res 116(3):576591 Li ZS, Wang K, Pan T, Sun YH, Liu C, Cheng YQ, Zhang H, Zhang HT, Wang DJ, Chen ZJ (2022) The evaluation of levosimendan in patients with acute myocardial infarction related ventricular septal rupture undergoing cardiac surgery: a prospective observational cohort study with propensity score analysis

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typically, preclinical studies administer doses based on animal model protocols whereas clinical trial dosing is carefully titrated