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Increased cytoplasmic calcium levels in cardiomyocytes, arising from chronic overloading or mitochondrial dysfunction, are associated with altered protein folding, ER stress, and induction of FGF21 ( By mediating expression of the oxidative stress response genes, FGF21 also protects cardiomyocytes from ischemic cell death (268) and oxidative injury caused by LPS-induced inflammation (269)

Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P, et al

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