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Conclusion GLP-1 agonists are a valuable addition to biologics in managing both inflammation and metabolic health in chronic autoimmune conditions

In an analysis of self-reported side effects of GLP-1s, insomnia was the most common psychiatric side effect but still accounted for less than 1% of all reported side effects

Additional symptoms including fatigue, cold intolerance, and reduced physical activity further compound weight management difficulties

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However, during pregnancy, your body produces 80% MORE of the toxic NAPQI metabolite (43% higher in first trimester), sulfation capacity decreases 33%, and glutathione depletes 36-87%