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On the immune side, obesity may cause M2 macrophages ferroptosis due to damage to iron-rich ATMs (MFe hi ) and antioxidant ATMs (Mox), and lead to Treg cells ferroptosis through reductions in NRF2, GPX4, and GCH1 levels
27 : 854862 Maes M, Smith R, Christophe A, Cosyns P, Desnyder R, Meltzer H
However, when a cell is under severe stresssuch as during a viral infection or a severe inflammatory flarethe ratio drops precipitously
Cell Metab (2020) 32:92037
Pandya, C
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