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Bipolar disorder is also commonly accompanied by circadian and sleep disturbances, which could be linked to increased KP activity, as TRP is shunted away from 5-HT synthesis reducing melatonin production and potentially disrupting sleep-wake regulation [233]

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The possible protective role of SIRT1 against the development of epileptogenesis and progression of epilepsy is related to different mechanisms including activation of autophagy and melioration of mitochondrial dysfunction which are induced by epilepsy

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