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Shankar K, Godse K, Aurangabadkar S, Lahiri K, Mysore V, Ganjoo A, et al

[1] [2] The most commonly reported adverse effects of semaglutide are gastrointestinal in nature, reflecting its mechanism of action on the digestive system

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If upregulation of citrate synthase occurred due to excess PPA in vivo and then PPA was removed in vitro , the high activity of citrate synthase in vitro would overproduce citrate and enhance the proximal portion of the TCAC, which preferentially produces NADH, the electron carrier metabolized by complex I

The two peptides act on different receptor systems