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Mar M, de Gregorio E, de Dios C, Roca-Agujetas V, Cucarull B, Tutusaus A, Morales A, Colell A

The metabolic disorder of UA mainly linked with abnormal urate transporters is an important cause of many diseases

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Common side effects , particularly during the initial weeks of treatment, include: Nausea (reported in up to 20% of patients) Diarrhoea or constipation Decreased appetite Abdominal discomfort or bloating Fatigue or mild headache These gastrointestinal symptoms are usually mild to moderate and tend to diminish as the body adjusts to the medication, typically within 24 weeks

Two-tailed unpaired Students t-test was applied