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Their experience suggested that the patchy hypopigmentation tended to resolve after 30-40 doses due to the evolution of a uniform skin-lightening effect Depletion of natural hepatic stores of glutathione: Hypothetically, long-term supplementation with any external synthetic compound may signal the body to stop its own production resulting in dependence on synthetic supplements

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PubMed Ng, F.M., Sun, J., Sharma, L., Libinaki, R., Jiang, W.J., & Gianello, R