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& Buitelaar, J
R., Canales, B
10.1007/s11033-014-3832-z[Epub ahead of print]
175 For the PPP enzymes, recent studies have discovered some inhibitors targeting on G6PD, such as NADP + analogs, the competitive inhibitor 6-aminonicotinamide (6-AN), noncompetitive inhibitors epiandrosterone and dehydroepiandrosterone (DHEA) which reduces the availability of NADPH and inhibits the cell growth
The antioxidant action of DTPA is derived from its ability to chelate Fe 3+ and thus prevent its reaction with superoxide and hydrogen peroxide, leading to formation of hydroxyl radicals (i.e., preventing HaberWeiss and Fentons reactions) ( 3+ DTPA is slowly reduced by superoxide, which results in the production of fewer hydroxyl radicals (Rahhal and Richter, 1988)
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