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Bmal1 and beta-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced beta-cell failure in mice

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Indeed, disruptions to epithelial barrier functions and a leaky gut are implicated in both intestinal and extraintestinal pathologies, including allergic and autoimmune conditions, inflammatory bowel diseases, irritable bowel syndrome and cancer 5

Nevertheless, the efficacy and safety of this approach must be rigorously evaluated before large-scale clinical application of stem cell drugs can be pursued