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However, different from the predicted binding mode of ghrelin, all the peptide moiety of ghrelin occupies the large cavity I while the octanoyl moiety attached to Ser3 of ghrelin extends into the small cavity II in the structure of ghrelin-bound GHSR (Fig
This transporter has similarities to the cystic fibrosis transmembrane conductance regulator (CFTR), which has been shown to be responsible for GSH flux from lung airway epithelial cells (Kogan et al , 2003), suggesting that ABC transporters might function in the transport of glutathione in mammalian cells
Marijic J et al
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37 The -glucosidase inhibitor acarbose, which suppresses several tumors, but simultaneously promotes kidney tumors of the Sprague Dawley rat, 175 has been recently reviewed
