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Science , 339(6119), 548554

Advanced protocol: Some researchers use up to 2.5 to 3 mg weekly, though evidence supporting additional benefit from higher doses remains limited while side effect potential increases

If there are bubbles, gently tap the syringe with your finger to move the bubbles to the top, then push the plunger slightly to expel the air

Safer options include a high-fibre diet (aiming for 30g daily), regular physical activity (at least 150 minutes of moderate-intensity exercise weekly), portion control, and behavioural approaches such as mindful eating