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It can also cause normal tissue to be displaced into the spinal canal through a herniation of the disc material, fracture of the bones in the canal, or of contents of the facet joints (synovial cysts)

Literature references: Pizzorno J

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Both TIn and Alk-TIn strongly inhibited the activity of mTYR with IC 50 values of 51.1 nM and 92.6 nM, respectively, which were both much lower than the commercial TYR inhibitor kojic acid (34.1 M) (Supplementary Fig