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48 As EPCs are considered to control the angiogenic switch of many physiological and pathological processes, such as neovascularization, 49 we assessed whether GLP-1(3236) plays a role in improving angiogenesis by regulating mitochondrial dynamics and metabolism

This methodical progression serves multiple functions: Allows physiological adaptation to receptor stimulation Reduces treatment discontinuation from gastrointestinal adverse events Enables monitoring of metabolic markers at each dose level The gradual approach addresses common tolerability challenges associated with incretin-based medications, particularly nausea, vomiting, and diarrhea that can occur with rapid dose introduction

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Semaglutide is also approved to help adults who are overweight or obese lose weight