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A retrospective cohort studies using the TriNeX database found that GLP-1 RA therapy combined with insulin was associated with a higher risk of diabetic retinopathy (HR, 1.21

Semaglutide is a GLP-1 receptor agonist while tirzepatide activates both GIP and GLP-1 receptors, which can lead to larger average weight loss in some trials

There, it triggers a massive proliferation of the gut microbe Lactobacillus delbrueckii

Including a protein source at each meal helps spread intake across the day

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