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Its cysteinyl thiol group neutralizes reactive oxygen species, donates electrons in glutathione peroxidase reactions, and forms conjugates with electrophilic xenobiotics via glutathione S-transferases

In the persistent presence of hepatic steatosis, there may be triggering of the oxidative stress process that is characterized in NAFLD by mitochondrial dysfunction, increased release of inflammatory mediators, increased production of oxidative stress byproducts, such as the MDA marker, or impaired redox balance, as well demonstrated by a decrease in GPx levels, or even by impaired inactivation of ROS by deficient reserves of antioxidant nutrients ( 4 , 22 )

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The increased potencies of the IGF-I variants may relate to the substantially increased plasma levels of IGF-binding proteins, particularly IGFBP-3, produced by the combined treatment of dexamethasone with IGF-I or the variants