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If the GHK-Cu has lower-than-stated purity or incomplete copper complexing, the actual administered dose and the active complex differ from the calculated values, compromising research validity

[2] The principle of 'more is better' does not apply to vitamin supplementation

In a 12-week clinical study, obese participants taking 1 mg of AOD-9604 daily lost about 2.62.8 kg (56 lbs) on average more than triple the weight loss of the placebo group

[103]) is consistent with an involvement of serotonin-kynurenine-inflammatory pathway, and supports the more general concept of inflammatory hypothesis in the pathophysiology of depression [104]