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Adults need 2.4 micrograms (mcg) daily, with slightly higher amounts during pregnancy or chestfeeding
10.1161/CIRCRESAHA.124.325550 65
Marked interindividual heterogeneity exists in platinum accumulation and toxicity severity among patients with similar cumulative doses, which is mainly mediated by genetic polymorphisms (e.g., GSTP1), epigenetic modifications, and baseline health status
Promotes Detoxification: Aids in the removal of toxins and heavy metals from the body
IGF1R autophosphorylation also recruits Shc, which leads to Grb2/SOS/Ras activation and downstream ERK1/2 phosphorylation
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