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Diets often leave you feeling constantly hungry and with a persistent sense of fatigue and a lack of energy

Adding glucagon or GIP receptor activation adds mechanisms that enhance energy expenditure, improve substrate utilization, and modify fat cell function

GLP-1 Drugs: Benefits Regulate Blood Sugar Levels Curb Appetite and Cravings Facilitate Weight Loss GLP-1 Drugs: Challenges Side Effects: Nausea, Vomiting, Diarrhea, Constipation Muscle Loss Supply Issues and Cost Difficult to Maintain Long-Term Not a Long-Term Solution While GLP-1 drugs may offer initial weight loss, potential drawbacks can include unpleasant side-effects, muscle-loss, and weight regain upon cessation

The route gap matters because peptides can behave differently depending on where and how they are administered

Data Availability The datasets generated during and/or analysed during the current study are available from the corresponding author upon reasonable request