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Additionally, shorter study duration, given constant weight loss, was correlated with a greater decrease in total GLP-1 in RCTs

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Ten of the 26 proteins whose regulation was not correlated with weight loss in the clinical trial (29) were also modulated in the GAN DIO-MASH mouse, supporting conserved semaglutide-responsive pathways in the model and suggesting that additional mechanisms may contribute to the hepatic effects of semaglutide in MASH

Clinical trials have demonstrated that Wegovy, when used alongside lifestyle modifications, can result in an average weight loss of approximately 15% of initial body weight over 68 weeks, as reported in the STEP 1 trial and referenced in NICE technology appraisal guidance (TA875)