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Once reconstituted, GHK-Cu has a finite stable window in refrigeration

Theoretical concerns: angiogenic activity warrants caution in patients with active malignancy (no tumour-promoting effects observed in any preclinical study, but oncology populations have not been formally studied)

In addition, men without full cystic fibrosis but who harbor mutations in the related gene (known as CFTR) are prone to low sperm counts and obstruction of the epididymis and ejaculatory duct

showed that early metastatic breast cancer cells had unique stem-like gene expression characteristics and prefer to proliferate and differentiate to produce advanced metastatic disease at the single-cell level (124)