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However, a few studies did find DPP-4is to be associated with a reduced risk of fractures compared to non-DPP-4i use (26, 27) or compared to glitazones (20)
For weight management, NICE has published technology appraisals for specific GLP-1 agents (semaglutide/Wegovy and liraglutide/Saxenda)
"Rapid weight loss can lead to drier skin," explains dermatologist Dr Miriam Rehbein
(6) This reduced binding may allow IGF-I LR3 to be transferred more rapidly to tissue sites, possibly resulting in higher local free concentrations
In rare cases, more serious side effects can occur, such as pancreatitis, gallbladder disease, or allergic reactions
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